Systems Biology in Toxicology and Environmental Health

Abstract

Systems Biology in Environmental Health: From the Genome to the Epigenome brings a systems biological perspective to recent findings that link environmental exposures to human disease. In addition to introductory chapters on molecular and cellular biology, toxicology, and computational biology, the book provides an assessment of systems-based tools that evaluate environmental health risks. This includes an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. The book then highlights environmental toxicants relevant to human health and disease, various high-throughput technologies, and computational methods, finally delving into the biological pathways associated with disease and the developmental origins of disease as it relates to environmental contaminants. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicologyIncludes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biologyPresents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them.