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https://lib.hpu.edu.vn/handle/123456789/23688| Title: | High content screening identifies a role for Na+ channels in insulin production |
| Authors: | Szabat, Marta Modi, Honey Ramracheya, Reshma |
| Keywords: | Cellular andmolecular biology Physiology Cellular biology Biotechnology Islet beta-cells Insulin synthesis Live-cell imaging Sodium channels High-content screening |
| Issue Date: | 2015 |
| Abstract: | Insulin production is the central feature of functionally mature and differentiated pancreaticβ-cells. Reduced insulin transcription and dedifferentiation have been implicated in type 2 diabetes, making drugs that could reverse these processes potentially useful. We have previously established ratiometric live-cell imaging tools to identify factors that increase insulin promoter activity and promote β-cell differentiation. |
| URI: | https://lib.hpu.edu.vn/handle/123456789/23688 |
| Appears in Collections: | Education |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 0488_Highcontentscreening.pdf Restricted Access | 2.04 MB | Adobe PDF |  View/Open Request a copy |
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