Difluoromethanesulfonyl hypervalent iodoniumylides for electrophilic difluoromethylthiolation reactions under copper catalysis

Abstract

Difluoromethanesulfonyl hypervalent iodonium ylides 2 were developed as electrophilic difluoromethylthiolation reagents for a wide range of nucleophiles. Enamines, indoles, β-keto esters, silyl enol ethers and pyrroles were effectively reacted with2affording desired difluoromethylthio (SCF2H)-substituted compounds in good to high yields under copper catalysis.