Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms

dc.contributor.author	Clouse, Ronald M.	en_US
dc.date.accessioned	2016-10-11T05:37:59Z
dc.date.available	2016-10-11T05:37:59Z
dc.date.issued	2015	en_US
dc.identifier.other	HPU4160623	en_US
dc.identifier.uri	https://lib.hpu.edu.vn/handle/123456789/23708	en_US
dc.description.abstract	Tissue inhibitors of metalloproteinases (TIMPs) help regulate the extracellular matrix (ECM) in animals, mostly by inhibiting matrix metalloproteinases (MMPs). They are important activators of mutable collagenous tissue (MCT), which have been extensively studied in echinoderms, and the four TIMP copies in humans have been studied for their role in cancer. To understand the evolution of TIMPs, we combined 405 TIMPs from an echinoderm transcriptome dataset built from 41 specimens representing all five classes of echinoderms with variants from protostomes and chordates.	en_US
dc.format.extent	14 p.	en_US
dc.format.mimetype	application/pdf	en_US
dc.language.iso	en	en_US
dc.subject	Evolution	en_US
dc.subject	Bioinformatics	en_US
dc.subject	Biomaterials	en_US
dc.subject	Collagen	en_US
dc.subject	Echinodermata	en_US
dc.subject	ECM	en_US
dc.subject	Holothuroidea	en_US
dc.subject	MCT	en_US
dc.subject	MMP	en_US
dc.title	Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms	en_US
dc.type	Article	en_US
dc.size	1.63MB	en_US
dc.department	Education	en_US