A Handbook of Transcription Factors

Abstract

The major goal of “A Handbook of Transcription Factors” is to provide a resource encompassing major facets of the molecular biology of TFs. As a Handbook, this volume is intended to provide a broad overview of this increasingly complex field, and is aimed at providing general context rather than fine details of specific examples. After decades of study of TFs at the molecular level, over 100,000 TF-related publications on Medline, hundreds of genome sequences, and continuous technological advances, a comprehensive review on TFs is not possible, even in book format. And since most reviews focus on specific topics, it can be difficult to get a perspective on what is known, what is not known, and what the global problems are. Topics in this book include the TF repertoire in both prokaryotes and eukaryotes, TF targeting and specificity, the properties of regulatory sequence, the interaction of TFs with chromatin, and mechanisms of TF action. The chapters are written by a team of experts, and highlight the current state of knowledge and research, as well as numerous challenges. I hope that this book will serve as a guide and reference for readers of all levels.