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https://lib.hpu.edu.vn/handle/123456789/23708| Title: | Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms |
| Authors: | Clouse, Ronald M. |
| Keywords: | Evolution Bioinformatics Biomaterials Collagen Echinodermata ECM Holothuroidea MCT MMP |
| Issue Date: | 2015 |
| Abstract: | Tissue inhibitors of metalloproteinases (TIMPs) help regulate the extracellular matrix (ECM) in animals, mostly by inhibiting matrix metalloproteinases (MMPs). They are important activators of mutable collagenous tissue (MCT), which have been extensively studied in echinoderms, and the four TIMP copies in humans have been studied for their role in cancer. To understand the evolution of TIMPs, we combined 405 TIMPs from an echinoderm transcriptome dataset built from 41 specimens representing all five classes of echinoderms with variants from protostomes and chordates. |
| URI: | https://lib.hpu.edu.vn/handle/123456789/23708 |
| Appears in Collections: | Education |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 0506_Phylotranscriptomic.pdf Restricted Access | 1.68 MB | Adobe PDF |  View/Open Request a copy |
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